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Malcolm Maden

Ph.D. University of Birmingham, UK, 1975

326 Bartram Hall

Research Interests

I study the relationship between development and regeneration in various organ systems including the limb, the lung, the skin and the nervous system. The guiding principle of this research is that by comparing the signaling molecules that operate in these two processes we can determine whether there are any fundamental differences (is regeneration a process of re-development?) and whether we can induce regeneration by re-awakening developmental pathways. Much of this work is centered on one signaling pathway, that of retinoic acid and the organisms used range from axolotls (the champion of regeneration) to mice.

Representative Publications

On skin regeneration:

SEIFERT, A,W., KIAMA, S.G., SEIFERT, M.G., GOHEEN, J.R., PALMER, T.M. & MADEN, M. (2012). Skin shedding and tissue regeneration in African spiny mice (Acomys). Nature 489, 561-5.

SEIFERT, A.W., MONAGHAN, J.R., VOSS, S.R. & MADEN, M. (2012). Skin regeneration in adult axolotls: a blueprint for scar-free healing in vertebrates.
PLoS One 7, e32875.

On limb regeneration:

MONAGHAN, J.R. & MADEN, M. (2013). Cellular plasticity during vertebrate appendage regeneration. Curr Top Microbiol Immunol. 367, 53- 74.

MONAGHAN, J.R., ATHIPPOZHY, A., SEIFERT, A.W., PUTTA, S., STROMBERG, A.J., MADEN, M., GARDINER, D.M. & VOSS, S.R. (2012). Gene expression patterns specific to the regenerating limb of the Mexican axolotl. Biol Open. 1, 937-48.

MONAGHAN, J.R. & MADEN, M. (2012). Visualization of retinoic acid signaling in transgenic axolotls during limb development and regeneration. Dev Biol. 368, 63-75.

SEIFERT, A.W., MONAGHAN, J.R., SMITH, M.D., PASCH, B., STIER, A.C., MICHONNEAU, F. & MADEN, M. (2012). The influence of fundamental traits on mechanisms controlling appendage regeneration. Biol Rev Camb Philos Soc. 87, 330-45.

KRAGL, M., KNAPP, D., NACU, E., KHATTAK, S., MADEN, M., EPPERLEIN, H-H. and TANAKA, E.M. (2009). Cells keep a memory of their tissue origin during axolotl limb regeneration. Nature 460, 60-5.

On nervous system regeneration and maintenance:

MADEN, M., MANWELL, L.A. & ORMEROD, B.K. (2013). Proliferation zones in the axolotl brain and regeneration of the telencephalon. Neural Dev. 8, 1.

JARVIS, C.I., GONCALVES, M.B., CLARKE, E., DORGUEL, M., KALINDJIAN, S.B., THOMAS, S.A., MADEN, M. & CORCORAN, J.P.T. (2010). Retinoic acid receptor-a signalling antagonizes both intracellular and extracellular amyloid-b production and prevents neuronal cell death caused by amyloid-b. Eur. J. Neurosci. 32, 1246-1255.

AGUDO, M., YIP, P., DAVIES, M., BRADBURY, E., DOHERTY, P., MCMAHON, S., MADEN, M. & CORCORAN, J.P. (2010). A retinoic acid receptor beta agonist (CD2019) overcomes inhibition of axonal outgrowth via phosphoinositide 3- kinase signalling in the injured adult spinal cord. Neurobiol. Dis. 37, 147-155.

MADEN, M. (2007). Retinoic acid in the development, regeneration and maintenance of the nervous system. Nat. Rev. Neurosci. 8, 755-65.

PO, S.L., YIP, P.K., BUNTING, S, WONG, L-F., MAZARAKIS, N.D., HALL, S.,MCMAHON, S., MADEN, M. & CORCORAN, J.P. (2006). Interactions between retinoic acid, nerve growth factor and sonic hedgehog signalling pathways in neurite outgrowth. Dev. Biol. 298, 167-175.

YIP,P.K., WONG, L-F., PATTINSON, D., BATTAGLIA, A., GRIST, J., BRADBURY, E.J., MADEN, M., MCMAHON, S.B. & MAZARAKIS, N.D. (2006). Lentiviral vector expressing retinoic acid receptor b2 promotes recovery of function after corticospinal injury in the adult rat spinal cord. Human Mol. Genet. 15, 1-12.

MADEN, M. (2006). Retinoids and the spinal cord. J. Neurobiol. 66, 726-738.

On lung regeneration:

HIND, M. & MADEN, M (2011). Is a regenerative approach viable for the treatment of COPD?. Br. J. Pharmacol. 163, 106-15.

HIND, M., GILTHORPE, A., STINCHCOMBE, S.V. & MADEN, M. (2009). Retinoid induction of alveolar regeneration: from mice to man? Thorax 64, 451-457.

STINCHCOMBE, S.V. & MADEN, M. (2008). Retinoic acid induced alveolar regeneration: critical differences in strain sensitivity. Am. J. Respir. Cell Mol. Biol. 38, 185-91.

MADEN, M. (2006). Retinoids have differing efficacies at inducing alveolar regeneration in a dexamethasone treated mouse model. Am. J. Resp. Cell Mol Biol. 35, 260-267.

On development:

REIJNTJES, S., ZILE, M.H. & MADEN, M. (2010). The expression of Stra6 and Rdh10 in the avian embryo and their contribution to the generation of retinoid signatures. Int. J. Dev. Biol. 54, 1267-1275.

WILSON, L.J., MYAT, A., SHARMA, A., MADEN, M. & WINGATE, R.J.T. (2007). Retinoic acid is a potential dorsalising agent in the late embryonic chick hindbrain. BMC Dev. Biol. 7, 138.

CHAMBERS, D., MADEN, M. & LUMSDEN, A. (2007). RALDH-independent generation of retinoic during vertebrate embryogenesis by CYP1B1. Development 134, 1369-1383.

MADEN, M., BLENTIC, A., REIJNTJES, S., SEGUIN, S., GALE, E. & GRAHAM, A. (2007). Retinoic acid is required for specification of the ventral eye field and for Rathke’s pouch in the avian embryo. Int. J. Dev. Biol. 51, 191-200.

REIJNTJES, S., RODAWAY, A. & MADEN, M. (2007). The retinoic acid metabolizing gene, CYP26B1, functions in zebrafish to pattern the cranial neural crest. Int. J. Dev. Biol. 51, 351-360.

MADEN M. (2006). Analysis of retinoid signaling in embryos. In Growth Factor Signaling in the Embryos. M.Whitman & A.K.Slater (eds) pp87-128. CRC Press, Boca Raton, Florida.

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