Representative Publications
On lung regeneration:
HIND, M. & MADEN, M (2011). Is a regenerative appraoch viable for the treatment of COPD?. Br. J. Pharmacol (in press).
HIND, M., GILTHORPE, A., STINCHCOMBE, S.V. & MADEN, M. (2009). Retinoid induction of alveolar regeneration: from mice to man? Thorax 64, 451-457.
STINCHCOMBE, S.V. & MADEN, M. (2008). Retinoic acid
induced alveolar regeneration: critical differences in strain
sensitivity. Am. J. Respir. Cell Mol. Biol. 38, 185-91.
MADEN, M. (2006). Retinoids have differing efficacies at inducing alveolar regeneration in a dexamethasone treated mouse model. Am. J. Resp. Cell Mol Biol. 35, 260-267.
HIND, M. & MADEN, M. (2004). Retinoic acid induces alveolar regeneration in the adult mouse lung. Eur. Resp. J. 23, 20-27.
MADEN, M. & HIND, M. (2004). Retinoic acid in alveolar development, maintenance and regeneration. Phil. Trans. R. Soc. Lond. B 359, 799-808.
On nervous system regeneration and maintenance:
JARVIS, C.I., GONCALVES, M.B., CLARKE, E., DORGUEL, M., KALINDJIAN, S.B., THOMAS, S.A., MADEN, M. & CORCORAN, J.P.T. (2010). Retinoic acid receptor-a signalling antagonizes both intracellular and extracellular amyloid-b production and prevents neuronal cell death caused by amyloid-b. Eur. J. Neurosci. 32, 1246-1255.
AGUDO, M., YIP, P., DAVIES, M., BRADBURY, E., DOHERTY, P., MCMAHON, S., MADEN, M. & CORCORAN, J.P. (2010). A retinoic acid receptor beta agonist (CD2019) overcomes inhibition of axonal outgrowth via phosphoinositide 3-kinase signalling in the injured adult spinal cord. Neurobiol. Dis. 37, 147-155.
PO, S.L., YIP, P.K., BUNTING, S, WONG, L-F., MAZARAKIS, N.D.,
HALL, S.,MCMAHON, S., MADEN, M. & CORCORAN, J.P. (2006).
Interactions between retinoic acid, nerve growth factor and sonic
hedgehog signalling pathways in neurite outgrowth. Dev. Biol. 298, 167-175.
YIP,P.K., WONG, L-F., PATTINSON, D., BATTAGLIA, A., GRIST, J.,
BRADBURY, E.J., MADEN, M., MCMAHON, S.B. & MAZARAKIS, N.D. (2006).
Lentiviral vector expressing retinoic acid receptor b2 promotes
recovery of function after corticospinal injury in the adult rat spinal
cord. Human Mol. Genet. 15, 1-12.
WONG, L-F, YIP, P.K., BATTAGLIA, A., GRIST, J., CORCORAN, J.,
MADEN, M., AZZOUZ, M., KINGSMAN, S.M., KINGSMAN, A.J., MAZARAKIS, N.D.
& MCMAHON, S.B. (2005). Retinoic acid receptor b2 promotes
functional regeneration of sensory axons into the adult rat spinal
cord. Nature Neurosci. 9, 243-250.
CORCORAN, J.P.T. & MADEN, M. (2004). Disruption of the
retinoid signalling pathway causes a deposition of amyloid b in the
adult rat brain. Eur. J. Neurosci. 20, 896-902.
CORCORAN, J.C., SO, P.L., BARBER, R.D., VINCENT, K.J.,
MAZARAKIS, N.D., MITHROPHANOS, K.A., KINGSMAN, S.M. & MADEN, M.
(2002). Retinoic acid receptor-b2 and neurite outgrowth in the adult
mouse spinal cord in vitro. J. Cell Sci. 115, 3779-3786.
CORCORAN, J.C., SO, P.L. & MADEN, M. (2002). Absence of
retinoids can induce motoneuron disease in the adult rat and a retinoid
defect is present in motoneuron disease patients. J. Cell Sci. 115, 4735-4741.
On development:
REIJNTJES, S., ZILE, M.H. & MADEN, M. (2010). The expression of Stra6 and Rdh10 in the avian embryo and their contribution to the generation of retinoid signatures. Int. J. Dev. Biol. 54, 1267-1275.
KRAGL, M., KNAPP, D., NACU, E., KHATTAK, S., MADEN, M., EPPERLEIN, H-H. and TANAKA, E.M. (2009). Cells keep a memory of their tissue origin during axolotl limb regeneration. Nature 460, 60-5.
WILSON, L.J., MYAT, A., SHARMA, A., MADEN, M. & WINGATE,
R.J.T. (2007). Retinoic acid is a potential dorsalising agent in the
late embryonic chick hindbrain. BMC Dev. Biol. 7, 138.
CHAMBERS, D., MADEN, M. & LUMSDEN, A. (2007).
RALDH-independent generation of retinoic during vertebrate
embryogenesis by CYP1B1. Development 134, 1369-1383.
MADEN, M., BLENTIC, A., REIJNTJES, S., SEGUIN, S., GALE, E.
& GRAHAM, A. (2007). Retinoic acid is required for specification of
the ventral eye field and for Rathke’s pouch in the avian embryo.
Int. J. Dev. Biol. 51, 191-200.
REIJNTJES, S., RODAWAY, A. & MADEN, M. (2007). The
retinoic acid metabolizing gene, CYP26B1, functions in zebrafish to
pattern the cranial neural crest. Int. J. Dev. Biol. 51, 351-360.
REINJTJES, S., BLENTIC, A., GALE, E. & MADEN, M. (2005).
The control of morphogen signalling: Regulation of the synthesis and
catabolism of retinoic acid in the developing embryo. Dev. Biol. 285, 224-237.
REIJNTJES, S., GALE, E. & MADEN, M. (2004). Generating
gradients of retinoic acid in the chick embryo: Cyp26C1 expression and
a comparative analysis of the Cyp26 enzymes. Dev. Dynam. 230, 509-517.
WILSON, L., GALE, E., CHAMBERS, D. & MADEN, M. (2004). The
role of retinoic acid in the dorsoventral patterning of the spinal
cord. Dev. Biol. 269, 433-446.
REIJNTJES, S., GALE, E. & MADEN, M. (2004). Generating
gradients of retinoic acid in the chick embryo: Cyp26C1 expression and
a comparative analysis of the Cyp26 enzymes. Dev. Dynam. 230, 509-517.
REIJNTJES, S., GALE, E. & MADEN, M. (2003). Expression of
the retinoic acid catabolising enzyme CYP26B1 in the chick embryo and
its regulation by retinoic acid. Gene Expr. Patterns 3, 621-627.
DIEZ DEL CORRAL, R., OLIVERA-MARTINEZ, I., GORIELY, A., GALE,
E., MADEN, M. & STOREY, K. (2003). Opposing FGF and retinoid
pathways control ventral neural patterning, neuronal differentiation
and segmentation during axis extension. Neuron 40, 1-20.
BLENTIC, A., GALE, E. & MADEN, M. (2003). Retinoic acid
signalling in the avian embryo identified by sites of expression of
synthesising and catabolising enzymes. Dev. Dynam. 227, 114-127.
Reviews:
MADEN, M. (2007). Retinoic acid in the development, regeneration and maintenance of the nervous system. Nat. Rev. Neurosci. 8, 755-65.
MADEN, M. (2006). Retinoids and the spinal cord. J. Neurobiol. 66, 726-738.
MADEN M. (2006). Analysis of retinoid signaling in embryos. In Growth Factor Signaling in the Embryos. M.Whitman & A.K.Slater (eds) pp87-128. CRC Press, Boca Raton, Florida.
WILSON, L. & MADEN, M. (2005). The mechanisms of dorsoventral patterning in the vertebrate neural tube. Dev. Biol. 282, 1-13.
MADEN, M. (2004). Retinoids in Lung Development and Regeneration. Current Topics in Dev. Biol. 61, 154-189.
MADEN, M. & HIND, M. (2003). Retinoic acid, a regeneration-inducing molecule. Dev. Dynam. 226, 237-244.
MADEN, M. (2002). Retinoid signalling in the development of the central nervous system. Nature Neurosci. 3, 843-853.
MCCAFFERY, P.J., ADAMS, J., MADEN, M. & ROSA-MOLINAR, E.
(2003). Too much of a good thing: retinoic acid as an endogenous
regulator of neural differentiation and exogenous teratogen. Eur. J. Neurosci. 18, 457-472.